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两种外体基因的circRNAs对于乳头甲状腺癌的诊断潜力

Lei Dai¹, Weibin Hu², Han Jiang^3,4

¹Department of Thyroid Surgery, Ningbo No. 2 Hospital, 41 Xibei Road, Haishu, Ningbo, 315000, ZJ, China.

International journal of clinical oncology

|August 11, 2023

概括

外体圆形RNAs (circRNAs) hsa_circ_0082002 和 hsa_circ_0003863 显示出作为皮皮类甲状腺癌 (PTC) 的诊断标记物的希望. 升高的水平与更具侵略性的PTC相关,表明它们在早期检测和预后方面的潜力.

科学领域:

分子瘤学分子瘤学
生物标志物发现发现
异构体生物学异构体生物学

背景情况:

外体内循环RNA (circRNAs) 对于癌症诊断非常有价值.
这项研究的重点是识别外体circRNAs用于乳头甲状腺癌 (PTC) 诊断.

研究的目的:

识别和评估特定的外体环RNAs作为PTC的潜在诊断生物标志物.
评估这些circRNA与PTC进展和临床病理特征的相关性.

主要方法:

通过circRNA微阵列选择候选circRNAs (hsa_circ_0082002,hsa_circ_0003863) 进行检测.
使用定量聚合酶链反应 (qPCR) 量化患者血清中的外体环RNA.
使用接收器操作特征 (ROC) 分析和通过生物信息学预测分子相互作用的诊断性能评估.

主要成果:

与健康对照和良性甲状腺瘤相比,PTC患者的外体hsa_circ_0082002和hsa_circ_0003863水平显著增加.
较高的circRNA水平与淋巴结转移和血管入侵相关,这表明与积极的PTC有关.
鉴定的circRNAs在各种存储条件下显示出血清中的稳定性.

结论:

两种外体circRNAs,hsa_circ_0082002和hsa_circ_0003863,被确定为PTC的潜在诊断标记物.
这些circRNAs可能通过与microRNAs和RNA结合蛋白的相互作用在PTC发生和进展中发挥作用.
这些发现突出了这些外体环RNAs在诊断PTC,特别是更具侵略性的形式方面的潜力.

关键词:

循环RNAs是一种循环RNA.诊断诊断诊断诊断诊断外基因组是外基因组的组成部分.乳头甲状腺癌是一种乳头甲状腺癌.

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