在阿尔茨海默病中神经精神病症状的网络分析
Grace J Goodwin1, Stacey Moeller1, Amy Nguyen2
1Department of Psychology, University of Nevada, Las Vegas (UNLV), Las Vegas, NV, USA.
Alzheimer's research & therapy
|August 11, 2023
概括
阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 中的神经精神症状相互关联. 针对抑制和激动/侵略的消毒可能会改善这些情况的整体症状.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 神经精神症状在阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 中显著影响生活质量.
- 有效的治疗目标需要更好地描述和分析这些神经精神病症状.
- 这项研究检查了认知障碍的老年人神经精神病症状的网络结构.
研究的目的:
- 研究患有MCI和AD的个体中神经精神症状的网络结构.
- 在神经精神病学概况中识别中心和相互关联的症状.
- 为开发有针对性的干预提供见解.
主要方法:
- 使用了国家阿尔茨海默氏症协调中心 (NACC) 统一数据集 (UDS).
- 分析了12494名患有MCI和AD的老年人的神经精神病 inventory问卷 (NPI-Q) 数据.
- 使用网络分析来估计症状关系和中心性.
主要成果:
- 在NPI-Q症状中确定了不同的连接模式.
- 脱抑制和激动/侵略成为网络中最核心的症状.
- 虽然抑郁症/性障碍症很常见,但它不是一个中心症状.
结论:
- 在MCI和AD中的神经精神症状是共患的,并且相互加强.
- 专注于抑制和激发/攻击的干预措施可能会带来更广泛的症状改善.
- 未来的研究将探索跨不同痴呆类型和人口统计数据的网络比较.
相关概念视频
Alzheimer's Disease: Overview
521
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
521
Alzheimer's Disease: Treatment
215
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
215
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Negative and Cognitive Symptoms of Schizophrenia
93
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
93


