骨质疏松症药物治疗对缺血性中风后功能结果的影响
Jong-Hee Sohn1,2, Chulho Kim1,2, Yerim Kim3
1Department of Neurology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 24252, Republic of Korea.
Journal of clinical medicine
|August 12, 2023
概括
骨质疏松症药物治疗 (OPT) 在急性缺血性中风患者中显著改善了功能结果. 治疗减少了依赖和功能不良的结果,在中风后的3个月和1年内增强了恢复.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨质疏松症在老年人中很常见,急性缺血性中风可能导致显著的功能障碍.
- 骨质疏松症药物治疗 (OPT) 对中风后功能恢复的影响尚不清楚.
研究的目的:
- 评估骨质疏松症药物治疗 (OPT) 对急性缺血性中风和骨质疏松症患者的功能结果的影响.
主要方法:
- 一个单一中心的注册中心确定了55岁以上的急性缺血性中风患者接受骨密度计.
- 患者被分为OPT和非OPT组,使用倾向分数匹配 (PSM) 来平衡共变量.
- 在PSM队列中使用多变量分析评估了一年功能结果.
主要成果:
- OPT组在1年后表现出较低的依赖风险 (OR,0.52) 和较差的功能结果 (OR,0.24).
- 接受OPT的患者有显著增加晚期功能改善的机会 (OR,6.16).
结论:
- 骨质疏松症药物治疗似乎有利于改善急性缺血性中风患者的功能结果.
- OPT可以减少依赖,改善功能恢复,并加强中风后的骨健康.
相关概念视频
Atherosclerosis IV: Nursing Management
23
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
23
Atherosclerosis III: Management
12
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
12
Peripheral Artery Disease IV: Nursing Management
12
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
12
Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Peripheral Artery Disease III: Interprofessional Care
11
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
11
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
189
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
189


