父亲年龄很重要:与精子标准的关联 - - 精子体的DNA完整性和甲基化概况
Marwa Lahimer1,2,3, Debbie Montjean4, Rosalie Cabry1,2
1Reproductive Medicine, Reproductive Biology & Genetics, University Hospital and School of Medicine, Picardie University Jules Verne, CHU Sud, 80054 Amiens, France.
Journal of clinical medicine
|August 12, 2023
概括
40岁以上的高级父亲年龄 (APA) 增加了精子DNA碎片化,降低了DNA甲基化. 生育能力评估应考虑对老年男性进行DNA碎片化测试.
科学领域:
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 安德罗学与人类学
背景情况:
- 先进的父亲年龄 (APA) 与精子质量降低和DNA完整性有关.
- 表观遗传变化,包括DNA甲基化变化,可能会影响生育结果.
- 需要进一步澄清APA,精子DNA完整性和甲基化之间的关系.
研究的目的:
- 调查晚年父亲年龄 (APA) 与精子参数之间的关联.
- 评估APA对精子DNA完整性和全球DNA甲基化概况的影响.
- 确定APA是否影响体外受精 (IVF) 的成功和临床结果.
主要方法:
- 对671名不育患者的回顾性分析.
- 精子分析包括运动性,形态和数量.
- 评估精子DNA完整性 (碎片化和脱凝) 和DNA甲基化水平.
主要成果:
- 40岁以上的男性的精子DNA碎片化明显高 (15%对9%,p=0.04).
- 在40岁以上的男性中,全球DNA甲基化水平显著下降 (2%对6%,p=0.03).
- 精子参数或DNA脱凝的显著差异与APA无关.
结论:
- 先进的父亲年龄 (40岁以上) 与精子DNA碎片化增加和DNA甲基化减少有关.
- 对于40岁以上接受生育评估的男性,建议对精子DNA碎片化进行评估.
- 与父亲年龄相关的精子表观遗传变化需要进一步研究它们对生育能力的影响.
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