患有神经发育障碍的儿童的睡眠特征和铁状况之间的相关性:一个横截面研究
Donatella Giambersio1,2, Lucia Marzulli3, Lucia Margari2
1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy.
Journal of clinical medicine
|August 12, 2023
概括
患有神经发育障碍 (NDD) 的儿童经常经历睡眠障碍. 这项研究发现,自闭症谱系障碍 (ASD) 儿童的铁状况与睡眠质量之间存在联系,这表明对睡眠问题NDD进行常规铁评估.
科学领域:
- 儿科神经学 儿科神经学
- 睡眠医学 睡眠医学
- 营养神经科学 营养神经科学
背景情况:
- 睡眠障碍在患有神经发育障碍 (NDD) 的儿童中很常见,例如自闭症谱系障碍 (ASD),注意力缺陷多动障碍 (ADHD) 和智力障碍 (ID).
- 这些儿童睡眠问题的原因各不相同,对缺铁的作用越来越感兴趣.
- 了解这些睡眠问题对于改善受影响儿童及其家人的生活质量至关重要.
研究的目的:
- 为了研究被诊断患有NDD的儿童的睡眠模式.
- 探索铁状况生物标志物与这些儿童睡眠的质量方面之间的潜在相关性.
- 为了确定铁的状态是否影响儿科NDD群体的睡眠障碍.
主要方法:
- 这项研究包括4-12岁的儿童,他们被诊断为ASD,ADHD或ID.
- 使用儿童睡眠习惯问卷 (CSHQ) 评估了睡眠特征.
- 血清中的费里丁,转激素和铁的水平从血液样本中测量.
主要成果:
- 所有儿童群体的平均CSHQ总得分都高于确定的切线值,这表明有明显的睡眠障碍.
- 在ASD组中,观察到帕拉索尼亚斯亚尺度得分和血清费里水平 (Rho = 0.354; p = 0.029) 之间存在显著的负相关性.
- 这些结果表明,NDD儿童的铁含量和睡眠质量之间存在潜在的关系.
结论:
- 这些发现表明,儿童的铁状况,睡眠质量和神经发育过程之间存在关联.
- 建议对所有患有NDD的患者进行常规睡眠评估.
- 对于经历睡眠障碍的NDD儿童,应考虑对铁状况生物标志物进行评估.
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