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在西班牙裔/拉丁裔临床基因队列中,睡眠时间,全因死亡率和心血管风险之间的U形关联
Mario Henríquez-Beltrán1, Jorge Dreyse2, Jorge Jorquera2
1Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Los Angeles 4440000, Chile.
Journal of clinical medicine
|August 12, 2023
概括
短 (≤6小时) 和长 (≥9小时) 的总睡眠时间 (TST) 都与增加全因死亡率和10年心血管风险有关,突出显示了U形的关联.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 不适当的睡眠时间与不良健康结果有关.
- 之前的研究表明,睡眠时间和死亡率之间存在U形关系.
- 心脏代谢风险与异常睡眠模式有关.
研究的目的:
- 调查总睡眠时间 (TST) 与全因死亡率之间的关联.
- 分析TST和10年心血管风险之间的关系.
- 检查智利队列中睡眠时间和健康风险之间的U形关联.
主要方法:
- 来自睡眠医学中心的1385名患者的前性队列研究 (SantOSA).
- TST的分类是短 (≤6小时),正常 (6-9小时) 和长 (≥9小时).
- 用Framingham 2008公式计算心血管风险的死亡率和后勤回归的调整危险比率 (aHR).
主要成果:
- 短TST (≤6小时) 与所有原因死亡率增加2.51倍的风险有关 (aHR: 2.51 (1.48-4.25)).
- 长时间的TST (≥9小时) 与3.97倍的全因死亡风险增加有关 (aHR:3.97 (1.53-10.29).
- 短时间和长时间的TST都与增加的10年心血管风险有显著联系,证实了U形的关联.
结论:
- 短时间和长时间的总睡眠时间是所有原因死亡的重要风险因素.
- 异常的睡眠时间 (短时间和长时间) 会增加10年内心血管疾病的风险.
- 维持正常睡眠时间 (6-9小时) 对于降低死亡率和心血管风险至关重要.
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