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免疫检查点抑制剂在细胞癌中的生物标志物

Spencer D Martin¹, Ishmam Bhuiyan², Maryam Soleimani^3,4

¹Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

Journal of clinical medicine

|August 12, 2023

概括

免疫检查点抑制剂 (ICI) 可以治疗细胞癌,但会导致自身免疫. 需要新的生物标志物来预测ICI反应,并尽量减少患者的风险.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物标志物发现发现

背景情况:

免疫检查点抑制剂 (ICI) 疗法改变了细胞癌 (RCC) 治疗方法,为以前息患者提供了潜在的治疗方法.
然而,ICI治疗可能会导致不良的自身免疫事件,并非所有患者都能从中受益,这凸显了对预测生物标志物的需求.
目前的生物标志物,如PD-L1表达,免疫透和瘤突变负担,在预测RCC中的ICI反应方面无效.

研究的目的:

审查生物标志物的机械基础和临床有效性,以预测细胞癌中ICI反应.
讨论既有和新兴的生物标志物,包括基因表达特征和蛋白质损失 (VHL,PBRM-1).
确定在临床试验中显示有前途的新生物标志物,以便在RCC治疗中更好地选择患者.

主要方法:

机械学基础的文献综述和生物标志物使用的理论依据.
讨论在细胞癌和其他癌症类型中的生物标志物有效性.
在临床试验中评估的新生物标志物的引入.

主要成果:

传统的生物标志物 (PD-L1,免疫透,瘤突变负担) 在细胞癌中缺乏预测能力.
新兴的生物标志物,包括基因表达特征和VHL/PBRM-1蛋白质的损失,显示出识别响应性RCC病例的潜力.
几种新型生物标志物正在研究中,并在正在进行的临床试验中显示出有希望的结果.

结论:

准确的生物标志物对于优化细胞癌中免疫检查点抑制剂治疗至关重要.
基因表达特征和特定蛋白质损失标记是预测RCCICI反应的有希望的途径.
对新型生物标志物的持续研究将改善细胞癌的患者选择和治疗结果.

关键词:

这就是PBRM-1的原因.在PD-L1中.这就是PD1 PD1.一个T细胞细胞.这是VHLVHL.生物标志物生物标志物免疫检查点抑制剂免疫检查点抑制剂免疫疗法免疫疗法细胞癌瘤是细胞癌.瘤突变负担瘤突变负担

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