描述Sjögren相关的疲劳:一种与ME/CFS不同的表型
Laura Kim1, Claudia Kedor1, Frank Buttgereit2
1Institute of Medical Immunology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Journal of clinical medicine
|August 12, 2023
概括
主要Sjögren综合征 (pSS) 患者经历显著的疲劳,但通常缺乏在肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 中看到的后劳动不适. 手握强度客观地测量了pSS中的疲劳.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 疲劳是Sjögren综合征 (pSS) 的主要和残疾症状.
- 肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 也具有疲劳和运动不耐受性的特点.
- 了解pSS中的疲劳及其与ME/CFS的重叠对于患者管理至关重要.
研究的目的:
- 在pSS患者中描述疲劳和相关症状.
- 为了调查pSS和ME/CFS之间潜在的症状重叠.
- 确定pSS中疲劳严重程度的客观指标.
主要方法:
- 使用问卷评估pSS症状严重程度和疾病活性.
- 根据ME/CFS的加拿大共识标准 (CCC) 评估pSS患者.
- 测量手握强度 (HGS) 和特定的自身抗体 (α1,α2,β1,β2,M3,M4).
主要成果:
- 一小组pSS患者报告严重疲劳,疼痛,抑郁和睡眠障碍.
- 在18名pSS患者中,有4人符合ME/CFS的CCC标准.
- HGS与疲劳严重程度相关,但与ME/CFS不同,力量在炼后恢复. 增加的β1,β2和M4自身抗体与疾病活性相关 (ESSDAI),而不是疲劳.
结论:
- 只有少数pSS患者符合ME/CFS标准.
- 后炼不适 (PEM) 在pSS中是不典型的,通常是由精神而不是身体炼引发的.
- 手握强度提供了一个客观的方法来评估初级Sjögren综合征的疲劳严重程度.
相关概念视频
01:21Fatigue
206
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
206
01:24Muscle Recovery and Fatigue
2.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.2K
01:18Factors Affecting Illness
4.3K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.3K
01:20Myasthenia Gravis: Overview and Treatment
1.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.6K
01:20COPD: Pathogenesis and Clinical Features
344
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
344
01:15Myasthenia Gravis: Diagnostic Tests
1.0K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.0K