在接受选择性TEVAR的老年和非老年患者中对发病率和死亡率结果的比较分析:系统性审查和元分析
Angelos Frisiras1, Emmanuel Giannas1, Stergios Bobotis1
1Faculty of Medicine, Imperial College London, Charing Cross Hospital, London W6 8RF, UK.
Journal of clinical medicine
|August 12, 2023
概括
胸内血管大动脉修复 (TEVAR) 在老年患者中显示出安全的外科手术期间发病概况. 虽然短期死亡率和长期存活率有利于年轻人群,但仅仅年龄不应对严重胸前大动脉病理的TEVAR进行禁忌.
科学领域:
- 血管外科 血管外科
- 老年医学 老年医学
- 心血管研究研究心血管研究
背景情况:
- 人口老龄化正在增加,需要有关老年患者胸内血管大动脉修复 (TEVAR) 的数据.
- 关于TEVAR在患有严重胸前大动脉病理的老年人中疗效和安全性的数据有限.
研究的目的:
- 评估TEVAR在老年患者中的可行性,疗效和安全性.
- 审查有关TEVAR在老龄化人口中的结果的现有文献.
主要方法:
- 一个对原始研究研究的元分析,评估TEVAR在老年患者中到2023年.
- 主要终点包括发病率 (神经/呼吸道并发症,内脏泄漏,停留时间).
- 二级终点是短期死亡率和长期存活率,使用Mantle-Haenszel方法进行分析.
主要成果:
- 确定了12项研究,其中7项比较了老年人和年轻人队列.
- 老年患者的住院时间更短.
- 在年龄组之间没有观察到患病结果的显著差异;年轻患者的生存率更好.
结论:
- 在老年患者中,由于安全的外科手术后发病概况,TEVAR不仅仅是基于年龄的.
- 需要对大型注册表进行进一步的研究,以验证在特定病理和程序类型 (可选/紧急) 中的发现.
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