在患有后病毒性嗅觉功能障碍的患者中,嗅觉表皮有异质损伤
Shu Kikuta1,2, Bing Han2, Tatsuya Yamasoba2
1Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Nihon University, 30-1, Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
Journal of clinical medicine
|August 12, 2023
概括
后病毒性嗅觉功能障碍 (PVOD) 选择性地损害了I类嗅觉感官神经元 (OSN). 这表明与PVOD相关的OSN损伤不均,取决于神经元类型.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
背景情况:
- 后病毒性嗅觉功能障碍 (PVOD) 是一种由普通感冒病毒引起的神经性疾病.
- 嗅觉感官神经元 (OSNs) 表达I类或II类气味受体基因,将它们分类为不同的神经元类型.
研究的目的:
- 调查PVOD中OSN损伤是否会对两个神经元类型产生均的影响.
- 为了区分PVOD特征与慢性鼻炎 (CRS) 和创伤后嗅觉功能障碍 (PTOD).
主要方法:
- 使用T&T和IVO气味进行的嗅觉测试给了PVOD,CRS和PTOD患者.
- 用GCaMP3成像分析了针对T&T和IVO气味的小鼠嗅觉球 (OB) 激活模式.
主要成果:
- 多变量分析确定了IVO气味反应,但不是T&T气味反应,作为PVOD的特征.
- 图像检测显示,IVO气味选择性地激活了OB区域的I类 OSN轴突.
- T&T气味广泛激活了与I类和II类 OSN轴突相关的OB区域.
结论:
- PVOD患者的反应表明,对I类OSN的偏好损伤.
- 在PVOD中OSN损伤似乎是异质的,并且取决于神经元类型.
更多相关视频
08:33Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
Published on: December 4, 2014
9.8K
09:02Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
1.5K
相关概念视频
Olfactory Receptors: Location and Structure
9.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.4K
Olfaction
44.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.5K
Physiology of Smell and Olfactory Pathway
8.7K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.7K
