循环的microRNA档案为早期心血管死亡在患有功能衰竭的患者与替代疗法治疗
Canan Kuscu1, Yamini Mallisetty2, Surabhi Naik1
1Transplant Research Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Journal of clinical medicine
|August 12, 2023
概括
在透析中患有功能衰竭的患者患有高心血管风险. 这项研究发现,更高的循环miR-129-1-5p水平可能预测这些患者的心血管过早死亡.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學.
- 分子生物学分子生物学
背景情况:
- 用替代疗法 (KFRT) 治疗功能衰竭的患者面临心血管疾病的高负担.
- 循环小非编码RNAs (c-sncRNAs) 正在成为潜在的生物标志物和心血管疾病的治疗点.
- 在预测KFRT患者心血管死亡率方面,c-sncRNAs的作用仍然在很大程度上是未知的.
研究的目的:
- 研究血液循环中的microRNAs (c-miRNAs) 与血液透析患者心血管疾病过早死亡之间的关联.
- 与幸存者相比,在死于心血管事件的患者中差异表达的特定c-miRNAs的识别.
主要方法:
- 一项试点病例控制研究,涉及50名死于心血管事件的血液透析患者和50名匹配的幸存者.
- 用下一代测序来分析血中的c-sncRNAs.
- 进行了差异表达分析,mRNA标预测和途径丰富分析.
主要成果:
- 发现五种c-miRNA在病例和对照之间表达不同.
- 在因心血管事件而死亡的患者中,miR-129-1-5p显著上调.
- 更高的循环miR-129-1-5p水平独立地与心血管死亡风险增加有关 (调整后OR: 1.68).
结论:
- 循环中的miR-129-1-5p可以作为一种新的预测生物标志物,用于在需要替代治疗的功能衰竭患者中预早心血管死亡.
- 需要进一步的研究来探索针对KFRT患者的miR-129-1-5p的治疗潜力.
更多相关视频
07:36Quantitative Real-Time PCR Evaluation of microRNA Expressions in Mouse Kidney with Unilateral Ureteral Obstruction
Published on: August 27, 2020
6.3K
06:48Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
Published on: April 29, 2022
2.3K
相关概念视频
01:24Chronic Kidney Disease II: Clinical Manifestations
30
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
30
01:25Chronic Kidney Disease I: Introduction
36
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
36
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
35
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
35
01:28Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
01:29Acute Kidney Injury II: Pathophysiology
30
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
30
01:22Acute Kidney Injury I: Introduction
30
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
30