慢性心房的患者中高尿血和心声学参数之间的关系
Mikel Jordhani1, Majlinda Cafka2, Joana Seiti2
1Internal Medicine Department, Korça Regional Hospital, 7001 Korça, Albania.
Journal of clinical medicine
|August 12, 2023
概括
超尿血症或高尿酸水平与慢性心房动 (AF) 患者的心房重塑有关. 尿酸升高与左心脏直径增加,左心室末缩直径增加和肺动脉压力相关.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
背景情况:
- 尿酸是心血管风险的标志物,与炎症和氧化应激相关.
- 有证据表明尿酸与心房动 (AF) 严重程度和心血管机制之间存在联系.
研究的目的:
- 评估慢性非膜AF (持续时间>5年) 患者的高尿血和心声学特征之间的相关性.
主要方法:
- 对107名患有慢性非膜AF的患者进行了病例控制研究.
- 患者被分为高尿血症 (>7.2 mg/dL) 和正常尿酸组.
- 心声学 (TTE) 分析了左心房直径 (LAD),左心室末缩直径 (LVESD) 和肺动脉压力 (PAP).
主要成果:
- 高尿路血症与增加的LAD显著相关 (OR:0.91,CI:0.84-0.99).
- 尿酸升高 (>8 mg/dL) 与LVESD (OR:0.82,CI:0.67-0.99) 和PAP (OR:0.91,CI:0.86-0.97) 的增加有关.
结论:
- 高尿路血症与心房重塑显著相关,特别是左心房直径增加.
- 高尿路血症也与LVESD扩大和升高的PAP相关,这表明对左心室形态和右心室功能有影响.
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