高血压心脏衰竭是什么
Filippos Triposkiadis1, Pantelis Sarafidis2, Alexandros Briasoulis3
1School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus.
Journal of clinical medicine
|August 12, 2023
概括
高血压显著导致心力衰竭 (HF),特别是心力衰竭与保留射出分数 (HFpEF). 这篇评论强调了高血压心力衰竭的炎症和自主神经系统方面.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 心脏衰竭研究研究
背景情况:
- 高血压在心力衰竭发展中的作用在临床实践中被低估了.
- 保持喷射分数 (HFpEF) 的心力衰竭通常同样归因于高血压,肥胖和糖尿病 (DM),尽管高血压是最常见的并发症.
- 与高血压不同,其他HFpEF并发症和HF之间的因果关系往往不清楚.
研究的目的:
- 提供对高血压性心力衰竭 (HF) 的当代概述.
- 为了强调炎症性质和自主神经系统 (ANS) 不平衡在高血压HF.
- 突出这些因素的病理生理学和治疗相关性.
主要方法:
- 这篇论文是对现有文献的综述和综合.
- 专注于流行病学证据和病理生理机制.
- 强调炎症和ANS失衡的作用.
主要成果:
- 高血压是HFpEF中最常见和最具影响力的并发症.
- 肥胖或DM中HF的发展是罕见的,没有同时存在的高血压或冠状动脉疾病 (CAD).
- 炎症和神系统失衡是高血压高血压的关键病理生理因素.
结论:
- 高血压是心力衰竭的主要驱动因素,特别是HFpEF.
- 在高血压心力衰竭中,炎症过程和自主神经系统功能障碍至关重要.
- 了解这些机制为管理高血压HF提供了治疗潜力.
相关概念视频
Heart Failure I: Introduction
16
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
16
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Heart Failure II: Pathophysiology
15
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15
Heart Failure IV: Classification and Diagnostic Evaluation
19
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
19
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
463
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
463
Heart Failure III: Clinical Manifestations
23
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
23


