患有外周动脉疾病的患者临床特征和结果的性别差异:回顾性分析
Giuseppe De Matteis1, Federico Biscetti2, Davide Antonio Della Polla3
1Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.
Journal of clinical medicine
|August 12, 2023
概括
这项研究发现,虽然主要不良肢体事件 (MALE) 和主要不良心血管事件 (MACE) 在性别之间相似,但患有外周动脉疾病 (PAD) 的男性经历了更多的截肢和心血管事件.
科学领域:
- 血管医学 血管医学
- 心血管研究研究心血管研究
- 基于性别的疾病差异.
背景情况:
- 周围动脉疾病 (PAD) 是一个重要的健康问题,死亡率和发病率很高.
- 与其他动脉样硬化疾病不同,PAD患者特征和结果的性别差异尚未得到充分确立.
研究的目的:
- 研究和定义PAD诊断的住院患者中临床特征和不良结果的基于性别的差异.
主要方法:
- 从2013年12月到2021年12月,对1640名住院PAD患者的回顾性分析.
- 主要终点:男性和女性PAD患者之间主要不良心血管事件 (MACEs) 和主要不良肢体事件 (MALEs) 的比较.
主要成果:
- 女性PAD患者年龄较大 (中位数为75岁与71岁).
- 女性接受了更多的重血管化血管造形手术 (29.8%对25.6%),而男性的截肢率更高 (19.9%对15.3%).
- 男性的下肢截肢,心血管死亡和心肌梗塞的概率更高,尽管PAD的严重程度相似.
结论:
- 虽然MALE和MACE的发病率在性别上没有显著差异,但男性经历了更不利的临床结果,包括截肢和心血管事件.
- 这些发现突出了PAD管理中的性别差异和结果,需要进一步调查和量身定制的临床方法.
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