在怀疑患有乳病的患者中,血清免疫球蛋白A总水平升高
Twan Sia1,2, Leeon Bacchus1, Evan Cunningham1
1Boston Specialists, 65 Harrison Ave #201, Boston, MA 02111, USA.
Journal of clinical medicine
|August 12, 2023
概括
在接受乳病检测的患者中,血清总免疫球蛋白A (IgA) 水平升高是常见的,可能不需要进一步调查. 男性性别与这些发现有关,这些发现往往缺乏临床意义.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 结核病查包括测试组织转谷氨酸酶-免疫球蛋白A (tTG-IgA) 和全血清IgA.
- IgA 缺乏症可能导致错误负的tTG-IgA 结果.
- 没有指导方针存在的偶尔增加的血清IgA总量在乳病检测期间.
研究的目的:
- 在怀疑患有乳病的患者中确定血清总IgA升高的患病率.
- 确定与偶尔总血清IgA升高相关的因素.
- 评估这些发现的临床意义和管理.
主要方法:
- 对848名被测试患有乳病的患者的回顾性图表审查 (2017年1月至2022年6月).
- 分析进一步的实验室检查和免疫学家对血清IgA总量升高的患者的随访.
- 外部验证使用来自斯坦福研究库的第二组33875名患者.
主要成果:
- 10.0%的患者 (85/848) 血清IgA总值升高,胆固醇检测结果为阴性.
- 男性的性别与血清总IgA的升高有关.
- 在正常IgA的患者中,便秘的发生频率更高.
- 第二个队列证实了患病率 (9.3%) 和与男性性别的关联.
结论:
- 偶尔发现患者血清IgA总量升高的情况是常见的.
- 血清IgA总量升高可能不具有临床意义,可能不需要进一步的治疗或检查.
- 男性的性别与血清IgA总量升高有关.
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