揭开慢性炎症,自身免疫和自发椎关动脉剖析之间的联系
Hao Li1, Shiyao Xu2, Beibei Xu1
1Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Journal of clinical medicine
|August 12, 2023
概括
自发的椎动脉解剖 (SCCAD) 是年轻成年人中中风的日益严重的原因. 本综述探讨了SCCAD,慢性炎症和自身免疫性疾病之间的联系,强调了有限但有意义的证据.
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 免疫学 免疫学 免疫学
背景情况:
- 由于成像技术的进步,自发性椎动脉剖析 (SCCAD) 的诊断越来越多.
- SCCAD是年轻人中风的重要原因,但其病理生理学尚不清楚.
- 现有研究表明,动脉壁的软弱和压力是关键因素.
研究的目的:
- 审查SCCAD,慢性炎症和自身免疫性疾病之间的关系.
- 探索这些条件之间的潜在病理生理机制.
- 识别当前知识的差距,并建议未来的研究方向.
主要方法:
- 审查现有文献,包括活检,病例报告和病例控制研究.
- 检查有关SCCAD炎症和自身免疫贡献的假设.
- 对SCCAD-炎症-自身免疫关系的现有证据的综合.
主要成果:
- 有证据表明,在SCCAD中,炎症变化和自身免疫力可能起作用.
- 目前,直接证据将SCCAD与慢性炎症和自身免疫性疾病联系起来很少.
- 假设存在,但可靠的临床数据有限.
结论:
- 需要进一步的研究来阐明连接SCCAD,炎症和自身免疫的确切机制.
- 需要更大的临床队列来验证拟议的链接.
- 动物模型可能为SCCAD病原体提供有价值的见解.
相关概念视频
Arteries of the Head and Neck
1.4K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
1.4K
The Arch of Aorta
746
The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
Encircling the heart, the coronary arteries form a ring-like structure before...
746
Psychoneuroimmunology: Cardiovascular Disease
51
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
51
Autoimmune Disorders
494
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
494
Aneurysm I: Introduction
13
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
13
Inflammatory Bowel Disease II: Crohn's Disease
291
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
291


