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在患有骨折的老年患者中,炎症性系统生物标志物和外科创伤之间的相关性
Flaviu Moldovan1,2, Adrian Dumitru Ivanescu1, Pal Fodor1
1Orthopedics-Traumatology Department, Faculty of Medicine, "George Emil Palade" University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.
系统性免疫炎症指数 (SII) 可以预测老年关节骨折患者的手术创伤. 更高的术后SII水平表明更大的创伤,有助于评估外科手术的侵入性.
科学领域:
- 整形外科 整形外科 整形外科
- 免疫学 免疫学 免疫学
- 老年医学 老年医学
背景情况:
- 部骨折在老年人中很常见,需要使用各种植入物进行手术干预.
- 评估外科创伤及其对老年患者的影响对于有效治疗至关重要.
研究的目的:
- 在老年关节骨折患者中,将血液计数衍生的炎症生物标志物与手术侵入性相关联.
- 评估中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),单细胞与淋巴细胞比率 (MLR) 和全身免疫炎症指数 (SII) 的预测值.
主要方法:
- 对129名患有部骨折的老年患者 (70岁以上) 进行了回顾性队列研究,这些患者接受了手术.
- 囊外 (内部固定) 和囊内 (血关节整形) 骨折组之间的结果比较.
- 术前和术后血细胞计数的分析,包括NLR,PLR,MLR和SII.
主要成果:
- 骨折组之间住院时间,手术持续时间和术后炎症标志物的显著差异 (p < 0.05).
- 手术后的NLR,PLR,SII和手术持续时间独立地与外科手术的侵入性相关 (p < 0.05).
- 术后SII>1564.74显示了手术创伤的预测价值 (58.1%的特异性,56.7%的灵敏性).
结论:
- 手术后的SII是一种可靠的生物标志物,用于量化老年关节骨折患者的外科创伤.
- 炎症生物标志物提供了对关节骨折手术程序的全身反应的见解.
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