以色列结性脊柱炎患者恶性瘤的风险和预测因素 - - 一项基于电子数据的回顾性电子数据研究
Polina Kagan1,2, Noy Horesh1,2, Howard Amital1,2
1Department of Medicine B, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 5262100, Israel.
Journal of clinical medicine
|August 12, 2023
概括
性脊柱炎 (AS) 患者面临更高的癌症风险,特别是固体瘤,中枢神经系统和脏恶性瘤. 糖尿病和IBD等并发症,以及DMARD治疗,增加了这种风险.
科学领域:
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 以前的研究表明,结性脊柱炎 (AS) 和癌症风险之间存在不一致的关联.
- 这种变化需要进一步调查AS患者面临的特定癌症风险.
研究的目的:
- 确定以色列结性脊柱炎患者的整体和局部癌症风险.
- 调查伴随性疾病和免疫调节疗法对该队列中的恶性瘤风险的影响.
主要方法:
- 一项回顾性电子数据研究包括5825名AS患者和28356名匹配对照 (2002-2018).
- 后勤回归分析用于计算局部特定恶性瘤的几率比率 (OR),并确定AS队列中的风险因素.
主要成果:
- 与对照组相比,AS患者的整体癌症风险增加 (OR=1.4).
- 观察到固体恶性瘤 (OR=1.5),中枢神经系统 (OR=3.72),脏 (OR=2.06) 和未知初级恶性瘤 (OR=3.06) 的风险增加.
- 在AS队列中,年龄较大,糖尿病,IBD和DMARD治疗与较高的固体恶性瘤风险相关,而NSAID显示有保护作用.
结论:
- 肌痛性脊柱炎与整体和特定癌症的风险增加有关.
- 在AS患者中恶性瘤的独立风险因素包括年龄,糖尿病,IBD和DMARD治疗.
关键词:
这就是DMARDs.无抗炎药 (NSAIDs) 是一种无抗炎药.结性脊柱炎是一种疾病.这是一种抗TNF的药物.癌症 癌症 癌症 癌症 癌症恶性瘤是一种恶性瘤.脊椎骨关节病变是一种脊椎骨关节病变.更多相关视频
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