大规模输血增加血清的度
Justyna Malinowska1,2, Milena Małecka-Giełdowska1,3, Katarzyna Pietrucha4
1Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.
Journal of clinical medicine
|August 12, 2023
概括
大规模输血红细胞会增加患者的血清水平,可能是由于输血细胞的轻度血解. 这一发现对于管理输血并发症至关重要.
科学领域:
- 输血医学 输血医学
- 临床化学 临床化学
- 血液学 血液学 血液学
背景情况:
- 大规模输血包装红细胞 (RBC) 是一个关键的干预措施,但可能导致诸如失磁血症等并发症.
- 是一种细胞内离子,可被输血红细胞显著影响,影响受体血液中的水平.
研究的目的:
- 为了研究大规模输血对血清度的影响.
- 探索红细胞中的细胞内和手术后的水平之间的关系.
主要方法:
- 对49名接受大量输血 (≥4单位/小时) 的患者进行了回顾性研究.
- 从医院数据库中分析实验室结果和患者病史.
- 在231个红细胞样本中测量细胞内的度,采用色度测量方法.
主要成果:
- 输血后24小时和48小时观察到平均血清的显著增加 (p < 0.00001).
- 死亡的患者血清度显著更高 (p < 0.05).
- 红细胞中的细胞内的中位数 (0.91 mmol/L) 低于参考值 (1.65-2.65 mmol/L).
结论:
- 输血的红细胞显著提高术后血清水平.
- 输血红细胞的轻度血液溶解可能会导致血清的增加,因为发现的细胞内度很低.
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