用免疫检查点抑制剂治疗患者的内分泌副作用:叙述性综述
Nicia I Profili1, Roberto Castelli1, Antonio Gidaro2
1Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
Journal of clinical medicine
|August 12, 2023
概括
免疫检查点抑制剂增强抗瘤免疫力,但由于免疫系统过度激活,可能导致不良事件. 本综述指导临床医生管理这些内分泌学副作用,以获得更好的患者护理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 免疫检查点抑制剂 (ICI) 是单克隆抗体,增强抗瘤免疫反应.
- ICI已改善了各种癌症的结果,但与免疫相关的不良事件 (irAEs) 有关.
- 据认为,irrAEs源于不受控制的免疫激活和潜在的T细胞交叉反应.
研究的目的:
- 为临床医生提供关于ICI诱导内分泌病变的早期诊断和管理的指导.
- 为了弥补影响关键内分泌腺的不良影响:甲状腺,垂体,上腺,胰腺和副甲状腺.
- 强调监测和及时治疗的重要性,以在ICI治疗期间提供最佳的患者支持.
主要方法:
- 对免疫检查点抑制剂及其内分泌不良事件的当前文献的综述.
- 综合有关irAEs机制,临床表现和管理策略的信息.
- 专注于内分泌腺,包括甲状腺,垂体,上腺,胰腺和副甲状腺.
主要成果:
- 免疫检查点抑制剂可以导致影响多个内分泌腺体的重大不良事件.
- 早期识别和管理对于减轻这些内分泌病变的影响至关重要.
- 了解潜在的免疫系统过度激活是管理这些副作用的关键.
结论:
- 内分泌不良事件是免疫检查点抑制剂治疗的一个重要问题.
- 临床医生需要明确的指导方针,以便及时诊断,监测和治疗这些影响.
- 有效地管理irAEs可以确保患者的安全,并支持继续使用这些重要的癌症疗法.
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