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扩散权重核磁共振 (MRI) 用于评估骨质细胞转移中的治疗反应 - - 一项可重复性研究

Maria Eveslage¹, Philipp Rassek², Arne Riegel³

¹Institute of Biostatistics and Clinical Research, University of Münster, 48149 Münster, Germany.

|August 12, 2023

概括

表面扩散系数 (ADC) 的测量显示出较低的可变性,使其可靠地用于评估骨质细胞转移中的治疗反应. 这种成像标志物有效地区分了可活和不可活的骨转移.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

骨质芽细胞转移对基于形态成像的治疗反应评估构成挑战.
表面扩散系数 (ADC) 是治疗反应的潜在成像生物标志物.
对于ADC的可靠性,与可活和不可活转移之间的差异相比,需要较低的测量方差.

研究的目的:

评估骨质细胞转移中体内ADC测量的可重复性.
为了确定可活性和不可活性转移之间的ADC差异是否与测量变异性相对显著.
评估ADC作为可靠的标志物治疗响应在骨质细胞转移.

主要方法:

对九名患者65例骨质细胞转移的反复体内ADC平均值的分析.
包括幻影测量以评估测量的可重复性.
使用PSMA-PET作为骨转移活力的替代品.
计算了可重复性系数,并比较了可活性和不可活性转移之间的平均ADC值.

主要成果:

在体内ADC中位测量的相对重复率 (%RC) 为12.9% (幻影:5.8%).
ADC的中值在595×10-6mm2/s到2090×10-6mm2/s之间.
与可活性转移相比,非可活性转移的ADC中值高出63% (p < 0.001).

结论:

对ADC的测量表明,相对于可活性转移和不可活性转移之间的差异,可重复性系数很小.
ADC测量满足了在骨质细胞转移中可靠评估治疗反应的技术要求.
ADC是一种有前途的成像生物标志物,用于监测骨转移的治疗疗效.

关键词:

看似的扩散系数.骨转移发生在骨髓中.扩散权重成像技术的使用.前列腺癌是前列腺癌.定量成像技术定量成像技术可以重复的可重复性.测试反测试研究研究

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