免疫细胞在口腔状细胞癌的发展中的作用
Vito Carlo Alberto Caponio1, Khrystyna Zhurakivska1, Lorenzo Lo Muzio1
1Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Cancers
|August 12, 2023
概括
免疫系统的免疫系统.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 口腔癌研究 在口腔癌研究.
背景情况:
- 免疫系统在预防瘤形成中的作用,包括口腔状细胞癌 (OSCC),是复杂的,并未完全理解.
- 从历史上看,作为癌症的障碍,与瘤相关的免疫和炎症可以矛盾地促进瘤发生和进展.
研究的目的:
- 审查免疫细胞在口腔潜在恶性疾病 (OPMD) 和OSCC的发展和进展中的双重作用.
- 突出免疫细胞表型和分子作为OSCC生物标志物的临床相关性.
- 讨论研究成果的翻译,以改善OSCC分类和精准医学.
主要方法:
- 对OPMD和OSCC中免疫细胞透研究的文献综述.
- 对T淋巴细胞,树突细胞,巨细胞和中性粒细胞的作用的证据分析.
- 检查免疫表型和分子的临床相关性.
主要成果:
- 透的免疫细胞表现出多方面的功能,抑制和促进癌症和癌症.
- 特定的免疫细胞,包括T淋巴细胞,树突细胞,巨细胞和中性粒细胞,都与OPMD和OSCC的发展有关.
- 免疫细胞表型和分子显示出作为OSCC生物标志物的潜力.
结论:
- 免疫微环境在口腔癌的进展中起着关键的,往往具有悖论的作用.
- 了解这些免疫动态对于开发OSCC的新生物标志物和精准医学策略至关重要.
- 对免疫细胞功能的进一步研究可以改善OSCC患者的分类和治疗结果.
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