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无形碳酸显示出抗癌性质,这归因于其缓冲能力
Yehudit Natan1, Yigal Dov Blum1, Amir Arav2
1Amorphical Ltd., 11 HaHarash st., Nes-Ziona 7403118, Israel.
Cancers
|August 12, 2023
概括
无形碳酸 (ACC) 通过减缓小鼠肺瘤生长表现出显著的抗癌作用. 此外,ACC治疗还减少了瘤体积和改变了基因表达,支持其作为抗恶性病原体的潜力.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
背景情况:
- 无形碳酸 (ACC) 是碳酸的一种非晶体形式.
- ACC是由聚合的纳米尺寸初级粒子组成的.
- 它的潜在抗癌作用,与缓冲能力相关,正在肺癌中进行研究.
研究的目的:
- 在肺癌模型中评估无形碳酸 (ACC) 的抗癌作用.
- 评估ACC对瘤生长,甲素B活性和基因表达的影响.
- 调查ACC的缓冲能力有助于其抗恶性病原性质的假设.
主要方法:
- 在体内研究中使用了小鼠的易斯肺癌 (LLC) 和A549人类肺癌细胞系.
- 携带瘤的小鼠每天接受ACC,西斯丁,ACC和西斯丁组合或载体的腹腔内注射.
- 分别在瘤组织和细胞中分析了甲素B活性和差异性基因表达.
主要成果:
- 在LLC和异种移植模型中,ACC治疗显著减缓了瘤生长率.
- 与对照组相比,ACC治疗的动物的瘤体积减少了44.83% (LLC) 和51.6% (异种移植).
- 联合ACC和西斯普拉丁治疗产生了74.75%的瘤体积减少;cathepsin B活性和抗瘤基因表达也受到调节.
结论:
- 这项研究支持无形碳酸 (ACC) 抗恶性缓冲假说.
- 通过减缓瘤生长,降低甲素B活性和改变基因表达,ACC显示出抗癌效应.
- 作为肺癌的治疗剂,ACC显示出有前途.
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