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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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模拟瘤微环境,但我们确切地说什么是"模型"?

Constantino Carlos Reyes-Aldasoro1

  • 1Department of Computer Science, City, University of London, London EC1V 0HB, UK.

Cancers
|August 12, 2023
PubMed
概括

在瘤微环境研究中",模型"一词具有多种含义. 虽然动物模型很常见,但数学和计算模型越来越多地用于癌症研究.

科学领域:

  • 在瘤学瘤学.
  • 生物信息学是一种生物信息学.
  • 科学方法科学方法学

背景情况:

  • 在科学研究中,特别是癌症研究中",模型"一词缺乏单一的定义.
  • 语境对于理解"模型"至关重要,从物理复制到抽象表示.
  • 瘤微环境研究涵盖了"模型"的各种解释,包括动物,体外,数学和计算方法.

研究的目的:

  • 审查和分类瘤微环境研究中使用的不同类型的"模型".
  • 量化评估MEDLINE数据库中各种"模型"类型的频率和趋势.
  • 分析不同类型模型中与癌症类型和微环境组件相关的特定关键词的使用情况.

主要方法:

  • 文献综述将瘤微环境模型分为四种类型:模型生物,体外,数学和计算.
  • 使用特定的关键词来确定模型频率,对MEDLINE数据库条目进行定量分析.
  • 评估不同模型类型的使用趋势随时间的推移.

主要成果:

  • 动物模型,特别是异种移植和小鼠模型,在历史上普遍存在,但显示下降趋势.
  • 数学模型,包括预后和风险模型,在频率和应用方面越来越多.
  • 该研究量化了各种模型类型和相关癌症研究关键词的使用情况.
关键词:
计算模型是一种计算模型.在体外模型模型中的体外模型.在体内模型的 in vivo 模型.数学模型是一个数学模型.模型生物模型生物.瘤微环境是一个微环境.

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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
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Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

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Last Updated: Jul 19, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
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Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

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结论:

  • 在瘤微环境研究中",模型"的定义和应用是多样化和不断发展的.
  • 在癌症研究中,从传统的动物模型向数学和计算方法的转变是明显的.
  • 研究文献的定量分析提供了关于瘤微环境建模技术不断变化的景观的见解.