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炎症性肠病中的粘性和标签环细胞结肠腺癌:一个病例对照研究

Benedetto Neri¹, Roberto Mancone¹, Luca Savino²

¹Gastroenterology Unit, Department of Systems Medicine, University "Tor Vergata" of Rome, 00133 Roma, Italy.

|August 12, 2023

概括

炎症性肠病 (IBD) 患者出现的粘膜癌和结晶环细胞结肠直肠癌 (CRC) 的频率更高. 这些特定的CRC基因型在IBD病例中在直肠中也更为普遍.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

炎症性肠病 (IBD) 与结直肠癌 (CRC) 的风险增加有关.
以前的报道表明,IBD患者的粘膜细胞和结环细胞腺癌的发病率较高.
了解IBD中CRC的特定基因病理特征对于风险分层和管理至关重要.

研究的目的:

确定IBD患者的粘膜和结环细胞结肠直肠腺癌的频率,与年龄匹配的非IBD对照组相比.
在IBD和非IBD组之间比较这些CRC基因型的特征.
在IBD人群中确定这些特定CRC亚型的潜在风险因素.

主要方法:

采用了一种病例控制研究设计.
包括2000年至2022年间被诊断患有CRC的患者.
患有CRC的IBD患者与基于年龄的CRC的非IBD对照进行了1:2匹配.

主要成果:

该研究包括120名CRC患者 (40名IBD,80名对照).
粘性/结环细胞腺癌在IBD患者 (42.5%) 的发生率高于对照组 (22.5%) (p=0.03).
在直肠CRC中,粘膜/结环细胞类型在IBD病例中 (66.6%) 与对照 (16.6%) (p=0.008) 相比,在IBD病例中明显高. 在IBD中没有特定的风险因素被确定.

结论:

与年龄相匹配的非IBD对照组相比,IBD患者的结肠直肠癌更频繁地表现为粘膜/结环细胞腺癌.
这些特定的CRC基因型在IBD患者的直肠中更为普遍.
可能需要进一步的研究来阐明IBD中这些亚型的特定风险因素和最佳管理策略.

关键词:

结肠直肠癌是什么意思炎症性肠病是一种炎症性肠病.粘膜性腺癌细胞瘤.封印环细胞腺癌瘤

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