炎症性肠道疾病中的肠外癌症:文学综述
Alessandro Massano1, Luisa Bertin1, Fabiana Zingone1
1Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University Hospital of Padova, 35128 Padova, Italy.
Cancers
|August 12, 2023
概括
患有炎症性肠病 (IBD) 的患者面临癌症的风险增加. 仔细考虑免疫调节剂和生物制剂至关重要,特别是有癌症史的人,需要个性化,多学科的方法.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),与肠道和肠外癌症 (EIC) 的风险增加有关.
- 人们对免疫调节剂和用于IBD治疗的生物疗法的潜在致癌作用存在担忧.
研究的目的:
- 审查IBD和EIC之间的关联.
- 评估免疫调节剂和生物治疗在IBD患者与EICs的病史中的安全性.
- 概述这些治疗方法的管理策略,在IBD患者之前或目前的EICs.
主要方法:
- 对现有文献进行系统审查.
- 对IBD和癌症风险的流行病学数据的分析.
- 对免疫调节剂和IBD的生物安全性进行临床试验数据的评估.
主要成果:
- 在IBD患者中,各种肠外固体瘤和血液恶性瘤的发病率较高.
- 免疫调节剂和生物疗法可能会增加特定EICs的风险.
- 这些疗法可以谨慎地给有恶性瘤病史的IBD患者使用.
结论:
- 对于需要免疫调节剂或生物制剂的IBD患者来说,个性化治疗决定是必不可少的,特别是那些有EIC史的人.
- 建议采用涉及瘤学家的多学科方法,以实现最佳的患者管理.
- 风险与益处的评估应指导这种患者群体的治疗选择.
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