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精准医学:疾病亚型和定制治疗

Richard C Wang¹, Zhixiang Wang²

¹Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

|August 12, 2023

概括

精准医学根据基因组学量身定制患者子组的治疗方法,超越基于证据的方法. 为了实现这一目标,需要将疾病分类为亚型,并为每一种疾病开发有针对性的治疗方法.

科学领域:

基因组学就是基因组学.
翻译医学是一种翻译医学.
医疗信息学医疗信息学

背景情况:

在人类基因组项目之后出现的精准医学与传统的基于证据的医学形成鲜明对比.
它可以根据疾病易感性和治疗反应为患者亚群量身定制治疗.
该模型旨在将患者分为生物学定义的子组,以改善结果.

研究的目的:

审查精准医学的历史,发展和未来的前景.
讨论精准医学的核心概念,原则,工具和应用.
专注于实现两个关键目标的进展:疾病亚型分类和向治疗的开发.

主要方法:

精准医学历史和发展的文献综述.
对概念,原则,工具和应用进行分析.
检查疾病分类和向治疗的进展情况.

主要成果:

精准医学代表了向个性化医疗保健的范式转变.
在了解疾病异质性和开发向治疗方面取得了进展.
审查强调了在这两个领域进一步取得进展的必要性.

结论:

精准医学对彻底改变患者护理具有重大前景.
成功实施取决于精确的疾病亚型和特定向治疗的可用性.
持续的研究和开发对于实现精准医学的全部潜力至关重要.

关键词:

大数据分析大数据分析生物标志物生物标志物电子健康记录电子健康记录功能精准医学是指功能精准医学.多种多种多种多种多种多种多种多种多种多种.药物学和医疗学药物学和医疗学精准医学是一门精准医学.分类子类型分类子类型提供量身定制的治疗.有针对性的治疗.

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