语言相关区域的灰质重塑取决于瘤侧向化
Lucía Manso-Ortega1,2, Laura De Frutos-Sagastuy1, Sandra Gisbert-Muñoz1,2
1Neurobiology of Language Group, Basque Center on Cognition, Brain and Language (BCBL), 20009 Donostia-San Sebastián, Spain.
Cancers
|August 12, 2023
概括
大脑瘤改变大脑结构,影响两个半球的语言网络. 瘤的位置会影响灰质变化的程度,这表明灰质重组支持大脑功能.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 神经外科 神经外科
背景情况:
- 大脑瘤,特别是在主导半球,可以影响语言横向化.
- 语言侧面化减少与语言网络中的结构灰质变化之间的关系尚未完全理解.
- 目前尚不清楚瘤诱导的干扰是否仅影响对侧语言区域或两个半球.
研究的目的:
- 为了调查大脑瘤是否会导致语言网络中的灰质结构重塑.
- 确定语言网络中断是否会影响两半球的宏观结构性质.
- 为了检查瘤横向化对灰质体积变化的影响.
主要方法:
- 基于voxel的形态测量 (VBM) 应用于高分辨率MR T1加权的MPRAGE图像.
- 分析包括31名左半球主导语言和瘤的成年患者 (18名左半球,13名右半球) 和71名健康对照.
- 用重复测量ANOVA分析了涉及语言功能的每半球10个感兴趣区域 (ROI),其中瘤横向化作为一个因素.
主要成果:
- 大脑瘤诱导语言区域及其相反的对应区域的全球体积变化.
- 这些体积变化的程度受到瘤侧面化 (位置) 的显著影响.
- 瘤的存在导致广泛的灰质变化,不仅限于病变的半球.
结论:
- 大脑瘤会在语言网络中引起显著的双边灰质体积变化.
- 瘤横向化是调解观察到的结构变化的关键因素.
- 研究结果表明,功能性大脑机制,包括语言处理,在瘤反应中受到灰质重组的支持.
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