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Mario W T Li¹, Sarah W Y Poon², Claudia Cheung³

¹Department of Paediatrics and Adolescent Medicine, The Hong Kong Children's Hospital, Hong Kong, China.

|August 12, 2023

概括

在患有垂体茎增厚 (PST) 的中国儿童中,生殖细胞瘤 (GCT) 比以前认为的更为常见. 关键预测因素包括男性性别和特定的MRI发现,指导诊断和管理.

科学领域:

儿科内分泌学儿科内分泌学
神经瘤学神经瘤学
放射学放射学是一门学科.

背景情况:

脑下垂体茎增厚 (PST) 在MRI上对患有内分泌疾病的儿童提出了诊断挑战.
朗格汉斯细胞囊胞症 (LCH) 和生殖细胞瘤 (GCTs) 是最常见的PST瘤病因.
癌症流行病学因种族而异,需要特定区域的数据.

研究的目的:

确定香港中华儿童中PST瘤病因的发病率.
在这个人群中确定瘤诊断的预测因子.

主要方法:

对全境电子数据库 (2010-2022) 的回顾性审查.
在MRI中包括19岁以下的内分泌病和PST (茎厚度≥3mm) 的患者.
排除患有先前存在的癌症或其他诊断疾病焦点的患者.

主要成果:

50% (14/28) 的患者接受了瘤诊断.
生殖细胞瘤 (GCTs) 是主要的瘤诊断 (46%),其次是LCH (4%).
瘤诊断的预测因素包括男性性别,PST≥6.5毫米,中部无味糖尿病和≥2类垂体激素缺乏.

结论:

在患有内分泌病症和隔离PST的中国儿童中观察到更高的GCT发病率.
识别的预测因素可以帮助亚洲医疗保健提供者的临床决策.
序列瘤标志物监测对于管理GCT至关重要.

关键词:

兰格拉汉斯细胞基细胞分裂中央糖尿病无味症 (英语:Central diabetes insipidus) 是一种糖尿病的发病症.内分泌病变 (内分泌病变) 是一种内分泌病变.胚胎细胞瘤的发生.加厚的垂体垂体茎.

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