在美国纯 (急性) 红色素瘤后的生存率:基于SEER的研究
Kriti Gera1, Daniela Martir1, Wei Xue2
1Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Cancers
|August 12, 2023
概括
急性红细胞白血病 (AEL) 影响所有年龄段,老年人的结果较差. 目前的化疗对AEL患者的生存率没有改善,这凸显了需要新的治疗方法.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 急性红细胞白血病 (AEL) 是一种罕见的急性髓性白血病 (AML) 亚型,涉及恶性红细胞前体的扩散.
- 对AEL的人口水平结果数据有限.
研究的目的:
- 分析急性红细胞白血病 (AEL) 的人口水平结果.
- 评估化疗对AEL患者存活率的影响.
主要方法:
- 对监测流行病学和最终结果 (SEER) 数据库 (2000-2019) 的回顾性分析.
- 包括组织学确认的AEL病例.
- 卡普兰-梅尔生存分析和统计学意义的日志等级测试.
主要成果:
- 总共分析了968名AEL患者;中位数年龄为68岁.
- 总生存率 (OS) 根据年龄组有很大差异,平均总生存率从1到69个月不等.
- 化疗改善了成人和儿科AEL患者的生存状况 (分别p < 0.0001和p = 0.004).
- 基于性别,种族,种族或收入,没有观察到显著的OS差异.
- 成人的中位 OS 在 2000-2019 年的诊断期内没有显著改善.
结论:
- AEL影响所有年龄组,主要是老年人.
- 目前的化疗药物对AEL患者的治疗结果不佳.
- 在过去的二十年中,AEL结果没有得到改善,这强调了对新型治疗剂的需求.
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