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综合分析确定DPP7是结肠直肠癌的预后生物标志物

Wei Zhang¹, Haidong Wang¹, Huadi Wang¹

¹Department of Medical Oncology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.

|August 12, 2023

概括

在结直肠癌 (CRC) 组织中,二乙酶7 (DPP7) 显著升高,与晚期疾病和生存率差相关. 这项研究确定DPP7为CRC患者的潜在诊断和治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

结肠直肠癌 (CRC) 由于预后不佳和复发和转移的高率,构成了重大挑战.
众所周知,二基酶7 (DPP7),一种前基酶,会影响淋巴细胞静止,但其在CRC预后中的作用尚不清楚.

研究的目的:

调查二乙酶7 (DPP7) 表达和结肠直肠癌 (CRC) 的临床病理特征之间的相关性.
评估DPP7作为潜在的诊断和预后生物标志物以及CRC的治疗点.

主要方法:

使用威尔科克森等级总和测试和后勤回归分析公开可用的CRC队列.
生物功能分析和基因组丰富分析 (GSEA) 以确定相关途径.
定量PCR (qPCR) 和免疫组织化学染色以验证手术样本中的DPP7表达.

主要成果:

与非瘤组织相比,CRC组织中的DPP7表达显著更高.
较高的DPP7水平与晚期N阶段,淋巴侵入和CRC患者的整体存活时间较短显著相关.
DPP7在功能上与神经活性联体受体相互作用和嗅觉转导信号通路有关.

结论:

DPP7是结直肠癌的有价值的诊断和预后生物标志物.
DPP7代表了CRC潜在的新治疗点,确定了向和小分子药物反应.

关键词:

DPP7 DPP7 DPP7 DPP7 DPP7 DPP7 DPP7 DPP7 DPP7 DPP7 DPP7 癌症预后生物标志物癌症预后生物标志物结肠直肠癌是什么意思

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