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清细胞细胞癌中的血清氧化和化压力标记物

Sabina Galiniak¹, Marek Biesiadecki¹, Mateusz Mołoń²

¹Institute of Medical Sciences, Medical College, Rzeszow University, Warzywna 1a, 35-310 Rzeszow, Poland.

|August 12, 2023

概括

系统性氧化应激在清细胞细胞癌 (ccRCC) 中显而易见. 氧化应激标志物随着瘤进展而增加,这表明抗氧化剂可能是ccRCC患者的治疗选择.

科学领域:

在瘤学瘤学.
生物化学生物化学
病理学病理学病理学

背景情况:

氧化应激与细胞癌 (RCC) 的发展和进展有关.
了解透明细胞RCC (ccRCC) 中的蛋白质修饰可以指导向治疗.
这项研究研究了ccRCC中的氧化和化应激.

研究的目的:

在ccRCC患者中评估氧化/化应激标志物.
探索氧化应激在ccRCC发育和进展中的作用.
为了将压力标记与瘤阶段,等级和血管侵袭相关联.

主要方法:

对氧化应激标记物的血清分析:高级氧化蛋白产物 (AOPP),醇组,阿马多里产物,3-甲酸,酸盐/酸盐,甲酸 (MDA),4-基-2-非,和总抗氧化能力 (TAC).
48名ccRCC患者与30名健康对照人群之间的比较.
评估与TNM分期,组织学等级和血管侵袭相关的关联.

主要成果:

ccRCC患者显示阿马多利产品,3-尼托铁素和酸盐/酸盐的含量增加,醇组和TAC降低.
氧化应激标志物 (AOPP,阿马多里,3-甲酸) 和疾病严重程度 (病理阶段,组织学等级) 是正相关的.
在血管侵袭患者中观察到酸盐/亚酸盐和MDA水平升高,表明随着疾病进展而增加的氧化应激.

结论:

系统性氧化应激存在于清细胞细胞癌中.
氧化应激标志物与瘤阶段和等级相关,突出显示它们在ccRCC进展中的作用.
这些发现表明抗氧化剂在管理ccRCC时具有潜在的治疗益处.

关键词:

3 - - 尼铁氨酸的使用.清晰癌症细胞癌细胞癌蛋白质氧化过程中的蛋白质氧化.血清的总抗氧化能力.

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