慢性阻塞性肺病和COVID-19患者的预后预测标记
Nicoleta Ștefania Motoc1, Iulia Făgărășan1, Andrada Elena Urda-Cîmpean2
1Department of Medical Sciences-Pulmonology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
一个新的预测模型确定了慢性阻塞性肺病 (COPD) 和COVID-19患者不良结果的关键因素. 这些包括功能衰竭,高LDH和低淋巴细胞计数,有助于预后预测.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 关于慢性呼吸道疾病对COVID-19结果的影响存在相互矛盾的报道.
- 慢性阻塞性肺病 (COPD) 是一种可能影响COVID-19预后的重大并发症.
研究的目的:
- 在COPD患者中开发COVID-19结果的预测模型.
- 为了确定临床,成像和血液标志物与这个患者群体的不良预后相关.
主要方法:
- 分析了165名COPD和COVID-19患者的前性观察队列.
- 后勤回归确定了不良结果的显著标记,包括ICU转移或死亡.
- 使用已识别的标记物的β系数开发了一个预测得分.
主要成果:
- 预后不佳的关键指标包括COVID-19的严重程度,功能衰竭,糖尿病,吸烟状况,氧气需求,高的LDH和CRP,以及低的乙氨基酸/淋巴细胞计数.
- 较高的死亡率与功能衰竭,受影响的肺叶数,入院时的氧气需求,高的LDH和低的淋巴细胞有关.
- 预测模型表明,如果得分为-2.80或更低,死亡的可能性为86.4%.
结论:
- 确定的COPD患者COVID-19的预后因素与仅COVID-19的预后因素是一致的.
- 开发的预测模型可以帮助预测伴随性COPD和COVID-19患者的结果.
- 早期识别高风险患者可能有助于指导临床管理和资源分配.
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