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由Enteromorpha prolifera介导的多糖和其Zn (II) 复合物对高糖高脂肪饮食养小鼠的低血糖活性产生调节作用

Liyan Li¹, Yuanyuan Li², Peng Wang²

¹Medical School, Huanghe Science and Technology College, Zhengzhou 450063, China.

Foods (Basel, Switzerland)

|August 12, 2023

概括

来自海洋的Enteromorpha prolifera多糖-Zn(II) 复合物 (EZ) 显示出强大的低血糖活性. 这种功能性食品成分通过改善小鼠的胰岛素耐药性和肠道微生物群来有效打击糖尿病.

科学领域:

海洋生物技术海洋生物技术
营养保健品营养保健品
糖尿病研究研究糖尿病研究

背景情况:

开发具有低血糖活性的功能性食品对于糖尿病管理至关重要.
海洋资源为新生物活性化合物提供了潜力.
虫多糖 (EP) 和其金属复合物对于治疗益处尚未得到充分研究.

研究的目的:

为了准备和表征Enteromorpha prolifera多糖体-Zn(II) (EZ) 复合物.
在高糖和高脂肪诱导的糖尿病小鼠模型中评估EZ的抗糖尿病作用.
调查EZ低血糖活性的潜在机制,包括其对肠道微生物群的影响.

主要方法:

从E. prolifera多糖 (EP) 和ZnSO4中制备EZ复合物.
使用UV-Vis光谱,红外光谱和单糖组成分析进行结构性表征.
糖尿病小鼠的药理评估,包括对胰岛素耐药性,失脂症,炎症,胰腺损伤,信号通路 (IRS/PI3K/AKT),GLUT2基因表达和肠道微生物群分析的评估.

主要成果:

EZ复杂的成功准备和特征.
通过改善胰岛素耐药性,失脂症和炎症,同时修复胰腺损伤,EZ显示出显著的低血糖效应.
在糖尿病小鼠中,EZ激活了IRS/PI3K/AKT信号通路,调节了GLUT2基因表达,并积极调节了肠道微生物群组成.

结论:

虫多种多糖-Zn(II) 复合体 (EZ) 具有强大的抗糖尿病特性.
EZ通过多种机制起作用,包括代谢调节和肠道微生物群调节.
EZ是功能性食品的有希望的候选成分,旨在用于补充剂和糖尿病管理.

关键词:

这是一种E. prolifera多糖化合物.Zn(II) 复杂的复合物.低血糖活动低血糖活动

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