用微流体方法制造的欧原醇封闭脂质体的制造和表征
Jessica Ghodke1, Sotirios I Ekonomou1, Edward Weaver2
1College of Health, Science and Society, University of the West of England, Coldharbour Ln, Bristol BS16 1QY, UK.
Foods (Basel, Switzerland)
|August 12, 2023
概括
微流体使得能够创建带有eugenol的脂质体,以提高食品安全. 这些脂质体表现出高的封装效率和稳定性,证明对欧原醇输送有效.
科学领域:
- 食品科学与技术 食品科学与技术
- 纳米技术 纳米技术
- 微流体学 微流体学
背景情况:
- 尤根醇表现出抗菌性质,但需要有效的输送系统.
- 脂质体是生物活性化合物的多功能纳米载体.
- 微流体技术为脂质体制造提供了精确的控制.
研究的目的:
- 开发和描述使用微流体的eugenol-loaded脂质体.
- 评估欧原醇脂质体的封装效率,稳定性和释放特征.
- 评估这些脂质体作为食品安全应用的输送载体的潜力.
主要方法:
- 使用微流体芯片 (蛇形和Y形) 用两个脂质:DSPC和DMPC制备脂质体.
- 研究了不同的流速比率 (FRR),以优化脂质体的形成.
- 在各种条件下评估了封装效率 (EE),物理稳定性 (大小,PDI,ZP) 和欧原醇释放动力学.
主要成果:
- 实现了高封装效率,DSPC 3:1的收益率为94.34%,DMPC 5:1的收益率为78.63%.
- 在pH 4 (99.86%) 时最大限度地释放欧原醇,使用Y形芯片中的DMPC.
- 脂质体在4,20和37°C的温度下60天表现出物理稳定性,FRR 5:1的DSPC显示出最高的稳定性.
结论:
- 微流体是一种适合生产稳定,高效的欧原醇载脂体的方法.
- 开发出来的脂质体表现出对受控欧原醇释放有希望的特性.
- 这些带有尤金醇的脂质体显示出作为有效的输送系统来提高食品安全的潜力.
相关概念视频
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Structure of Lipids
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...


