系统性炎症对中枢神经系统的影响:神经元损伤的无声历史
Mara Verónica Millán Solano1,2, Citlaltepetl Salinas Lara1,3, Carlos Sánchez-Garibay1,3
1Red MEDICI, Carrera Médico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de Mexico, Tlalnepantla 54090, Mexico.
International journal of molecular sciences
|August 12, 2023
概括
中枢神经系统 (CNS) 感染会通过炎症引起损伤. 这项研究解释了神经炎症和中枢神经系统损伤机制,没有微生物或炎症细胞,重点关注质细胞的作用.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 中枢神经系统 (CNS) 感染,如脑膜炎和脑炎,通过炎症导致神经组织损伤.
- 在诸如败血症等疾病中出现的全身性炎症,可以通过改变血脑屏障 (BBB) 和血脑脊髓液屏障 (BCSFB) 功能来影响中枢神经系统.
- 细菌脂聚糖 (LPS) 触发炎症媒介并损害可以到达中枢神经系统的分子,诱导无菌神经炎症.
研究的目的:
- 在神经炎症的背景下阐明中枢神经系统损伤的机制.
- 为了解释涉及无菌神经炎症的病理生理相互作用.
- 详细介绍神经炎症期间神经元损伤中的质细胞的作用.
主要方法:
- 审查和解释关于神经炎症和中枢神经系统损伤的现有文献.
- 分析炎症媒介和神经质细胞在神经元损伤中的作用.
- 在没有直接的微生物入侵或炎症细胞透的情况下,专注于病理生理过程.
主要成果:
- 神经炎症涉及质细胞 (星球细胞,微质细胞,寡质细胞) 释放有害物质,如细胞因子,化学因子和活性氧/物种.
- 神经元经历形态和功能变化,可能启动神经退行过程.
- 由LPS等系统性因素引发的无菌性神经炎症可以损害BBB/BCSFB的完整性,并导致神经元损伤.
结论:
- 质细胞是神经炎症期间中介神经元损伤的关键参与者,即使没有直接感染.
- 系统性炎症和中枢神经系统障碍之间的相互作用对于启动神经炎症过程至关重要.
- 了解这些无菌通路对于理解神经退行过程和开发向疗法至关重要.
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