TFF3作为移植患者的诊断生物标志物
Karolina Rogulska1, Iwona Wojciechowska-Koszko1, Barbara Krasnodębska-Szponder2
1Department of Diagnostic Immunology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
International journal of molecular sciences
|August 12, 2023
概括
肠道三叶草因子3 (TFF3) 显示出用于监测移植患者的诊断潜力. 它在血清和尿液中的水平与肌素和EGFR相关,有助于移植后的护理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物发现发现
- 移植免疫学 移植免疫学
背景情况:
- 在病患者中,肠道三叶草因子3 (TFF3) 水平波动.
- TFF3是一种由各种细胞类型分泌的蛋白质.
- 监测移植接受者需要可靠的生物标志物.
研究的目的:
- 为了评估TFF3在移植患者的诊断价值超过一年.
- 评估生物材料类型和移植后时间对TFF3水平的影响.
- 调查TFF3,肌素和估计的淋巴细胞过率 (eGFR) 之间的关系.
主要方法:
- 研究包括19名成年移植接受者和5名健康对照.
- 移植后24-48小时,6个月和12个月收集的血液和尿液样本.
- 使用ELISA和xMap Luminex测定法确定TFF3水平.
主要成果:
- 在移植后的早期阶段,与对照组和后期阶段相比,观察到血清TFF3的显著差异.
- 在尿液TFF3和肌素之间发现的相关性,以及在移植后早期与eGFR的逆相关性.
- 在移植后6个月和12个月,血清/尿液TFF3和eGFR之间发现了显著的相关性.
结论:
- TFF3显示出作为监测移植接受者的生物标志物的潜力.
- 与肌素和eGFR一起测量TFF3可以提供宝贵的诊断见解.
- 诊断方法的选择 (ELISA与Luminex) 显著影响TFF3度值.
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