在结肠直肠癌中准KRAS:床边审查的长椅
Fernand Bteich1,2, Mahshid Mohammadi2,3, Terence Li2,3
1Department of Medical Oncology, Montefiore Medical Center, Bronx, NY 10467, USA.
International journal of molecular sciences
|August 12, 2023
概括
针对结肠直肠癌 (CRC) 中的KRAS突变,新的抑制剂正在推进. 组合疗法对于克服KRAS突变CRC治疗中的耐药性至关重要.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 大肠直肠癌 (CRC) 是一种复杂的疾病,经常出现KRAS突变 (高达40%).
- KRAS突变通过RAS/MAPK途径驱动瘤发生,影响扩散和存活.
- 历史上,KRAS作为预后和预测生物标志物,直至最近,直接治疗向有限.
研究的目的:
- 审查目前对针对CRC中的KRAS突变的理解和发现.
- 探索对KRAS抑制剂耐药性的机制.
- 讨论KRAS突变的CRC.治疗策略的发展.
主要方法:
- 关于KRAS抑制剂的最新临床前和临床研究的综述.
- 对KRAS突变瘤的适应性抵抗机制的分析.
- 综合现有和新兴的治疗策略.
主要成果:
- 几种KRAS等位基特异性抑制剂正在临床试验的后期阶段.
- 新的代理和准策略正处于早期开发阶段.
- 由于强大的适应性抵抗,组合疗法是必不可少的.
结论:
- 向KRAS突变代表了CRC治疗的重大进展.
- 了解和克服抵抗机制对于有效治疗至关重要.
- 未来的CRC治疗可能会涉及对KRAS突变患者的组合策略.
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