虹膜素:在肥胖中可能是脂肪组织功能障碍的标志物
Laura Tomasello1,2, Maria Pitrone1, Valentina Guarnotta1,2
1Laboratory of Endocrinology and Regenenerative Medicine "Aldo Galluzzo", Università di Palermo, 90133 Palermo, Italy.
International journal of molecular sciences
|August 12, 2023
概括
脂肪组织的炎症会破坏脂肪细胞的功能,导致肥胖. 虹膜素水平可以预测脂肪组织损伤和肥胖风险.
科学领域:
- 脂肪组织生物学 脂肪组织生物学
- 肥胖的病原体是肥胖的病原体.
- 细胞因子信号传递
背景情况:
- 脂肪组织 (AT) 稳态依赖于平衡脂肪生成和细胞外矩阵 (ECM) 重塑.
- 瘤亡因子-α (TNFα) 和虹膜素是参与AT功能的关键细胞因子.
- 肥胖与AT功能障碍和炎症有关.
研究的目的:
- 调查TNFα诱导的脂肪原体 (ASC) 和脂肪细胞 (AMC) 中的ECM重塑.
- 探索素在肥胖期间脂肪组织损伤中的作用.
- 分析核因子-卡帕 (NF-kB) 途径的参与.
主要方法:
- ASC和AMC用TNFα进行治疗.
- 分析了TIMP-1,TWIST-1和PPARγ的表达.
- 评估了MMP-2和MMP-9的活性,并通过齐摩图进行了评估.
- 使用ELISA测量素水平.
主要成果:
- TNFα治疗诱导了TIMP-1/TWIST-1失衡,降低了AMC中的PPARγ.
- 过度激活MMP-9有助于ECM重塑,损害脂肪生成和脂质储存.
- 在肥胖患者中发现了炎症,脂肪虹膜素分泌和循环虹膜素之间的积极相关性.
结论:
- NF-kB通路作用者启动脂肪组织功能障碍.
- 虹膜可以作为脂肪组织损伤和肥胖的预测因素.
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