从减少主义的方法到系统免疫学的方法,了解瘤微环境
Nicholas Koelsch1, Masoud H Manjili1,2
1Department of Microbiology & Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
International journal of molecular sciences
|August 12, 2023
概括
了解瘤微环境 (TME) 需要一种系统免疫学方法. 分析免疫细胞相互作用揭示了集体功能对于新型癌症免疫疗法至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 系统生物学 系统生物学
背景情况:
- 瘤微环境 (TME) 是一个复杂的生态系统,其免疫细胞具有双重的亲和抗瘤功能.
- 目前针对个体免疫细胞的减少主义治疗策略在癌症治疗中有效性有限.
- 最近在多学科技术的进步使得一个更全面的系统免疫学视角.
研究的目的:
- 探索系统免疫学方法如何彻底改变对TME的理解.
- 提出免疫细胞之间的互联网相互作用创造了与单个细胞角色不同的集体功能.
- 突出识别和调节这些集体功能在癌症免疫治疗中的潜力.
主要方法:
- 对TME应用的系统免疫学原则的审查和讨论.
- 整合多omics数据来分析免疫细胞互联网相互作用.
- 在TME中理解集体免疫功能的概念框架.
主要成果:
- 在TME内部的免疫细胞网络相互作用产生新兴的集体功能.
- 这些集体功能独立于个体免疫细胞类型的功能.
- 在TME中发现免疫模式是理解这些集体行为的关键.
结论:
- 一个系统免疫学方法提供了从TME的减少主义观点的范式转变.
- 了解集体免疫功能对于开发有效的癌症免疫疗法至关重要.
- 调节已识别的免疫模式对癌症治疗具有治疗潜力.
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