精选糖的水解产物乳酸盐-晶体结构和微生物活动
Justyna Samaszko-Fiertek1, Artur Sikorski1, Barbara Dmochowska1
1Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
International journal of molecular sciences
|August 12, 2023
概括
乳有效合成糖化物,其中D-gluconic酸化物和酸L-ascorbate显示有前途的抗菌活性. 化L-甲酸的水解产生了盐,而不是预期的化物.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 微生物学 微生物学
背景情况:
- 乳是有机合成中的多功能前体.
- 糖化物是一种具有潜在生物应用的化合物.
- 酸 (维生素C) 具有独特的化学特性.
研究的目的:
- 用各种乳基质合成糖化物.
- 为了研究L-亚斯科布酸与水溶解的反应.
- 评估合成化合物的抗微生物和抗真菌活性.
主要方法:
- 从商用和定制合成的乳中合成糖化物.
- 化L-甲酸的水解.
- 使用核磁共振 (NMR) 和X射线晶体学进行结构阐明.
- 用于稳定性评估的热重力测量分析 (TGA).
- 对格拉姆阴性和格拉姆阳性细菌和真菌菌株进行微生物学测试.
主要成果:
- 乳被证明是糖化合成的有效基质.
- L-亚斯科布酸产生了化L-亚斯科布酸盐,而不是预期的化.
- D-gluconic acid hydrazide和hydrazinium L-ascorbate表现出显著的抗微生物和抗真菌活性.
- 热重力测试表明,酸L-ascorbate的耐用性较低.
结论:
- 糖化物可以有效地从乳前体合成.
- 由于它们的生物活性,Hydrazinium L-ascorbate和D-gluconic acid hydrazide显示出进一步研究的巨大潜力.
- 在水解溶解中L-甲酸的独特反应性需要进一步研究.
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