人类副甲状腺正常,超塑性和腺状腺腺体中的Telocytes/CD34+流体细胞
Lucio Díaz-Flores1, Ricardo Gutiérrez1, Miriam González-Gómez1,2
1Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 La Laguna, Spain.
International journal of molecular sciences
|August 12, 2023
概括
太阳细胞/CD34+ stromal 细胞 (TCs/CD34+ SCs) 在人甲状腺中被发现,形成连接系统,并参与腺体发育和常见的疾病,如增生和腺瘤.
科学领域:
- 内分泌学 在内分泌学.
- 历史学 历史学 历史学
- 细胞生物学 细胞生物学
背景情况:
- 细胞/CD34+ stromal 细胞 (TCs/CD34+ SCs) 在各种组织中被识别,但它们在甲状腺腺中的作用以前未被探索.
- 了解副甲状腺中TCs/CD34+SCs对于了解腺体结构和功能至关重要.
研究的目的:
- 研究TCs/CD34+SCs在正常,发育中的和病理改变的人类副甲状腺的存在,位置,排列和行为.
- 描述TCs/CD34+SCs与甲状腺微环境中的其他细胞和细胞外成分的相互作用.
主要方法:
- 免疫组织化学和超结构分析被用来检查甲状腺组织.
- 这项研究评估了正常,发育中的,多发性和腺瘤的人类副甲状腺腺体中的TCs/CD34+SCs.
主要成果:
- 正常副甲状腺体中的TCs/CD34+SCs表现出独特的形态,形成相互连接的网络并与原I结合,但在膜内血管和脂肪细胞周围不存在.
- 这些细胞存在于发育中的副甲状腺,周围的和脂肪细胞中.
- 在超塑性腺体中,TCs/CD34+SCs在体和腺外巢周围突出;它们也存在于腺瘤边缘,但在腺瘤组织中基本上不存在.
结论:
- TCs/CD34+ SCs是人类副甲状腺层的重要组成部分,在腺体发育和常见病理中发挥作用.
- 它们的特征特征,包括连接功能和与原I的关联,在甲状腺上下文中得到证实.
- 在各种副甲状腺疾病中TCs/CD34+SCs的差异分布突显了它们在腺体平衡和疾病中的参与.
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