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第二个细胞外环的动力学控制转换器合的激活的GPCRs

Marcel M Wygas1, Jeannette M Laugwitz2, Peter Schmidt2

  • 1Faculty of Life Sciences, Institute of Biochemistry, Leipzig University, Brüderstr. 34, 04103 Leipzig, Germany.

International journal of molecular sciences
|August 12, 2023
PubMed
概括

将细胞外循环2 (ECL2) 与跨膜螺旋3 (TM3) 连接的二硫化键对于激活的G蛋白合受体 (GPCR) 信号通路至关重要. 破坏这种联系会影响G蛋白和阿雷斯的招募,影响受体活性.

关键词:
在被逮捕后被捕.保存的二硫化物.电子偏磁共振 (EPR) 是一种电子偏磁共振.细胞外循环的循环.功能选择性的功能选择性.类G蛋白结合受体 (GPCR) 是一种

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