Sir2和糖在酵母慢性衰老过程中解释了奎尔素对长寿的影响
Francesco Abbiati1, Stefano Angelo Garagnani1, Ivan Orlandi1,2
1Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
International journal of molecular sciences
|August 12, 2023
概括
奎尔 (QUER) 通过减少氧化应激和改变碳代谢来延长寿命. 这种天然化合物增强葡萄糖生成和三糖的产生,促进老化酵母细胞的寿命.
科学领域:
- 细胞和分子生物学 细胞和分子生物学
- 衰老研究研究 衰老研究
- 代谢途径 代谢途径
背景情况:
- 奎尔 (Quercetin,简称QUER) 是一种具有众所周知的健康益处的黄类化合物,包括抗衰老特性.
- 确切的分子点和途径负责QUER的亲长寿效应仍然不清楚.
- 酵母的时间衰老作为研究哺乳动物细胞衰老的验证模型.
研究的目的:
- 调查奎尔素对酵母慢性寿命 (CLS) 的影响.
- 阐明潜在的分子机制,特别关注代谢变化和氧化应激.
- 为了确定Quercetin是否影响与衰老相关的碳代谢途径.
主要方法:
- 在时间老化过程中的二氧化转移时,补充Quercetin到酵母培养物.
- 测量时间寿命 (CLS) 和评估氧化应激水平.
- 碳代谢的分析,包括发酵副产品,糖醇代谢和葡萄糖生成.
主要成果:
- 奎尔丁补充剂显著增加了慢性寿命 (CLS).
- 这种寿命延长与减少的氧化应激相关.
- 奎尔素通过增强的C2副产品和甘油代谢促进了对葡萄糖生成的合成代谢,涉及烯酸酸碳素激酶和L-甘油3-酸盐通路.
- 增加的葡萄糖生成导致了更高的三糖水平,有助于CLS扩展.
结论:
- 奎尔素通过减轻氧化应激减轻酵母的时间寿命.
- 奎尔特特别调节碳代谢,增强葡萄糖生成和三糖积累.
- 这些由Quercetin驱动的代谢转变是其在老化模型中观察到的长寿效应的关键.
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