在COVID-19中肠道微生物群失生症:预防和治疗的调制和方法
Virna Margarita Martín Giménez1, Javier Modrego2,3, Dulcenombre Gómez-Garre2,3,4
1Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, San Juan 5400, Argentina.
International journal of molecular sciences
|August 12, 2023
概括
COVID-19 破坏了肠道微生物群,减少了有益的细菌并增加了炎症. 调节肠道微生物群可能为预防和治疗SARS-CoV-2感染提供新的策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- COVID-19与炎症和氧化应激有关,使患者的结果恶化.
- SARS-CoV-2 感染会改变肠道微生物群,减少有益的细菌并产生有害的代谢物.
- 肠道功能失调会加剧炎症,在COVID-19患者中产生有害的循环.
研究的目的:
- 审查COVID-19患者肠道失调的证据.
- 探索COVID-19中肠道微生物群,炎症和氧化应激之间的联系.
- 研究肠道微生物群调节在COVID-19预防和治疗中的潜力.
主要方法:
- 关于COVID-19和肠道微生物群的研究文献综述.
- 对关联肠道失调,炎症和SARS-CoV-2的分子机制的分析.
- 检查短链脂肪酸 (SCFA) 和它们在COVID-19中的作用.
主要成果:
- COVID-19与肠道失调相关,其特点是减少有益细菌和SCFA,如丁酸盐.
- 肠道功能失调会放大炎症和氧化应激,导致疾病的严重程度.
- 有益的肠道细菌产生可能抑制冠状病毒S蛋白的代谢物.
结论:
- 肠道功能失调在COVID-19病变发生过程中发挥着重要作用.
- 准肠道微生物群为针对SARS-CoV-2的新型治疗策略提供了一个有希望的途径.
- 保持肠道健康和微生物多样性对于打击COVID-19至关重要.
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