大脑干调节帕金森症诱导的面部或面部传感运动功能障碍
Glauce Crivelaro Nascimento1,2, Gabrielle Jacob1, Bruna Araujo Milan1
1Department of Oral and Basic Biology, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, Brazil.
International journal of molecular sciences
|August 12, 2023
概括
帕金森病会导致面部问题. L-DOPA治疗会使这些情况恶化,影响下肌肉和三角神经系统的神经,导致疼痛和运动变化.
科学领域:
- 神经科学是一个神经科学.
- 肌肉生理学 肌肉生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 帕金森病 (PD) 涉及机动和非机动或面部症状.
- 虽然L-DOPA是主要的治疗方法,但它可能会引起诸如动力障碍等副作用.
- 三角生体系统和部肌肉与PD的面部表现有关.
研究的目的:
- 在PD中调查侧肌 (LPMs) 和三角骨系统的病理生理机制.
- 分析PD诱导的口面变化和L-DOPA诱导的运动障碍效应.
- 关联神经激活与肌肉和疼痛反应.
主要方法:
- 创建了一个单边的6-氧多巴胺诱导的半帕金森症小鼠模型.
- 评估了运动 (动力障碍) 和感觉反应.
- 在三角核和LPM中分析了Fos-B,质细胞和肌肉纤维形态.
主要成果:
- 半帕金森症和运动不良的老鼠显示过敏症的增加.
- 在功能障碍的老鼠中,LPMs显示了改变的髓纤维,糖溶性代谢和炎症标志物.
- 增加的Fos-B表达和质激活在特定的脑细胞核中被观察到.
结论:
- 脊柱三核的激活与PD大鼠的口面感觉障碍有关.
- 由L-DOPA诱导的动力障碍可能涉及LPM疲劳和运动/面部核的激活.
- 这些发现突出了PD,L-DOPA和口面功能之间的复杂相互作用.
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