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Updated: Jul 19, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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二硫胺类同类:合成,抗GBM活性和药物规划

Akshaya Murugesan1,2, Saravanan Konda Mani3, Ramesh Thiyagarajan4

  • 1Department of Biotechnology, Lady Doak College, Madurai Kamaraj University, Thallakulam, Madurai 625002, India.

International journal of molecular sciences
|August 12, 2023
PubMed
概括

二胺衍生物被合成并对质母细胞瘤 (GBM) 进行了测试. 化合物AL106通过抑制热氨酸受体激酶A (TrkA) 显示出显著的抗GBM活性,表明潜在的向治疗.

关键词:
这是一种RTK抑制剂.二硫胺的类似物是二硫胺.细胞死亡是细胞死亡.质母细胞瘤 (glioblastoma) 是一种药物动力学 药物动力学

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