有氧运动训练改善了处理和心脏功能,因为大动脉狭窄导致心力衰竭的老鼠
Vítor Loureiro da Silva1, Gustavo Augusto Ferreira Mota1, Sérgio Luiz Borges de Souza1
1Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, Brazil.
International journal of molecular sciences
|August 12, 2023
概括
有氧运动训练 (AET) 改善了大动脉狭窄症 (AoS) 引起的心力衰竭的老鼠的心脏功能. 甲增强了的处理,并恢复了关键蛋白质水平,在多个层面上显著改善了心脏表现.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 分子生物学分子生物学
背景情况:
- 有氧运动训练 (AET) 是一种公认的治疗心脏病的干预措施.
- 在心力衰竭模型中,关于AET对 (Ca2+) 处理和心脏功能的影响存在相互矛盾的数据,特别是大动脉狭窄 (AoS).
研究的目的:
- 为了研究AET对Ca2+处理和心脏功能的影响,AoS诱导心力衰竭的老鼠.
- 为了澄清AET对与Ca2+调节相关的蛋白质表达的影响.
主要方法:
- 威斯塔尔老鼠接受了AoS的手术诱导或假手术.
- 这些组接受了为期10周的跑步机运动训练 (AET) 或保持久坐.
- 通过心声学,隔离的乳头肌肉和心肌细胞来评估心脏功能.
- 分析了Ca2+处理和蛋白质表达 (SERCA2a,NCX).
主要成果:
- 在AoS大鼠中,AET减轻了腹功能障碍和改善了腹功能.
- AET增强了休息后收缩反应和SERCA2a/L型Ca2+通道活动.
- AET使SERCA2a和NCX的改变蛋白质表达正常化,改善肌纤维Ca2+的响应性.
结论:
- 在AoS引起的心力衰竭中,AET改善心脏功能和Ca2+处理.
- AET恢复了SERCA2a和NCX水平,增强了细胞的Ca2+流入和肌纤维敏感性.
- 运动训练在细胞,组织和腔室水平上为心脏功能障碍提供了治疗效益.
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