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长期呼吸道疾病中的上皮-半机关过渡机制:一个共同的过程来准?
Angélique Mottais1, Luca Riberi2, Andrea Falco2
1Pole of Pneumology, ENT, and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain, 1200 Brussels, Belgium.
International journal of molecular sciences
|August 12, 2023
概括
皮质到介质细胞的转变 (EMT) 驱动肺部疾病,导致慢性炎症,纤维化和呼吸道重塑. 了解EMT机制可以为不可逆转的肺损伤带来新的治疗方法.
科学领域:
- 肺部医学 肺部医学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 表皮细胞转换为介质细胞 (EMT) 是一种细胞过程,其中表皮细胞获得介质细胞的表型.
- EMT与各种肺部疾病有关,包括肺癌,间歇性肺部疾病,喘,COPD,囊性纤维化和支气管病.
- 肺部疾病中的慢性炎症可以触发EMT,导致亲纤维组织修复和渐进的肺功能障碍.
研究的目的:
- 审查慢性呼吸道疾病中纤维化变化和气道重塑的机制.
- 探索EMT在肺部疾病病原发生中的作用.
- 确定潜在的治疗目标,以防止不可逆转的结构性肺损伤.
主要方法:
- 在慢性肺病中对EMT的研究的文献综述.
- 分析涉及EMT的信号通路和监管机制.
- 综合有关纤维变化和气道改造的信息.
主要成果:
- 在慢性肺病中,EMT有助于异常组织修复和结构变化.
- 在不同肺部疾病中,EMT涉及常见的信号通路,但具体的触发因素可能有所不同.
- 由EMT诱导的益肌性变化导致逐渐的器官功能障碍和肺功能受损.
结论:
- 在慢性肺部疾病中,EMT是纤维化和呼吸道重塑的关键过程.
- 进一步了解EMT机制对于开发有针对性的疗法至关重要.
- 旨在调节EMT的干预措施可以预防或限制不可逆转的结构性肺损伤.
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