自然产品的辐射调节功能与向放射调节和外体生物发生的miRNA之间的联系
Jen-Yang Tang1,2, Ya-Ting Chuang3,4, Jun-Ping Shiau5
1School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
International journal of molecular sciences
|August 12, 2023
概括
自然产品与放射治疗相结合可以影响外体微RNA (miRNAs) 来保护健康细胞并使癌细胞敏感. 本综述探讨了这些天然产品如何影响miRNA介导的放射调节和外体生物发生.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 外体对癌症的进展和转移至关重要.
- 放射治疗的效果可以通过外体微RNAs (miRNAs) 来调节.
- 将放射治疗与天然产品相结合,有可能改善癌症治疗,但缺乏对外体相关机制的详细理解.
研究的目的:
- 研究放射性天然产品在调节外体miRNAs中的作用.
- 探索这些天然产品对miRNA介导的辐射反应和外体生物生成的影响.
- 在自然产品增强放射治疗中阐明miRNA-辐射调节-外体生物发生轴.
主要方法:
- 关于具有辐射保护和miRNA调节作用的天然产品的PubMed/Google Scholar文献综述.
- 使用miRDB和基因本体学数据库 (MGI) 进行生物信息分析,以确定参与辐射反应和外体生物发生的miRNA目标.
- 以目标为中心的分析,以确定自然产品中共享的miRNA和目标.
主要成果:
- 一些天然产品单独表现出辐射保护和miRNA调节的特性.
- 自然产品调节外体miRNAs,影响辐射反应和外体生物发生.
- 确定了共享的miRNA和点,突出了放射调节和外体调节的协调机制.
结论:
- 在自然产品调节miRNA的地方存在一个明确的轴,通过外体生物生成影响癌细胞辐射敏感化和非癌细胞辐射保护.
- 这个轴为理解自然产品介导的放射治疗效应提供了一个框架.
- 对这一轴的进一步研究可以优化联合放射治疗和天然产品策略.
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